Modulatory effects of nitric oxide-active drugs on the anticonvulsant activity of lamotrigine in an experimental model of partial complex epilepsy in the rat

Table 1 Effect of 7-Nitroindazole, L-arginine and LTG administration alone and in combination on the amplitude of evoked responses measured at the maximum of the effect.

Treatment	Control value	Test value	D%	F (_1,18)	P
7-NI	18.70 ± 2.40	4.10 ± 1.19	-78.00%	295.14	<0.0001
7-NI + LTG	19.1 ± 2.02	1.40 ± 0.51	-92.67%	717.45	<0.0001
LTG	19.40 ± 3.13	1.70 ± 0.82	-91.23%	298.37	<0.0001
L-Arg	19.70 ± 2.66	24.70 ± 3.46	+25.38%	13.06	0.002
L-Arg + LTG	19.1 ± 4.88	13.7 ± 6.66	-28.27%	4.26	0.054

Values are expressed as mean ± standard deviation. Test values are compared to control values. D%: percent difference between test and control values. Control and post-pharmacological treatment values were statistically analysed using an ANOVA test followed by Bonferroni post-hoc test. F: variance ratio. Differences were considered statistically significant when P was less than 0.05.

ISSN: 1471-2202