| |
Mouse
|
Human
|
Homologuea
|
|---|
|
Measure
|
Promoterb
|
Intergenicc
|
Scored
|
Promoterb
|
Intergenicc
|
Scored
|
Completee
|
Conservedf
|
Scoreg
|
|---|
|
Total genes
|
18071
|
13475
| |
19794
|
15178
| |
13365
|
516
| |
|
CREB targets
|
1050
|
279
|
0.64
|
1389
|
388
|
0.64
|
830
|
356
|
0.83
|
|
zif268 targets
|
1382
|
200
|
0.81
|
1203
|
244
|
0.74
|
1136
|
166
|
0.56
|
|
% CREB genes
|
5.81%
|
2.07%
| |
7.02%
|
2.56%
| |
6.21%
|
2.66%
| |
|
% zif268 genes
|
7.65%
|
1.48%
| |
6.08%
|
1.61%
| |
8.50%
|
1.24%
| |
- a The homologue dataset was contructed using the Homologene resource on the NCBI website (http://www.ncbi.nih.gov).
- b The promoter region is the area from -1,000 to 200 bp relative to transcription start.
- c Intergenic regions refer to an area 50,000 bp away from transcription start. Fewer intergenic regions are available than genes because of gaps in sequencing.
- d The score is determined by the positive predictive value which is a conservative estimate of the fraction of found transcription factor binding sites that are true hits. It is calculated as (%Observed - %Intergenic)/(%Observed).
- eThe complete homologue numbers refer the the number of human/mouse homologous pairs identified using the Homologene resources.
- f The conserved dataset is a subset of the Homologene dataset that consists of only those genes for which homologous pairs contain a conserved binding site.
- g The quality is determined by the positive predictive value which is a conservative estimate of the percentage of found transcription factor binding sites that are true hits. It is calculated as (%Conserved Observed - %Predicted Conserved)/(%Conserved Observed).
