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Table 1 Gp120 reduced astroglial cell viability as expressed by % trypan blue positive cell counts in 10 experiments. NAC (0.5–5 mM) antagonized this effect.

From: N-acetylcysteine prevents HIV gp 120-related damage of human cultured astrocytes: correlation with glutamine synthase dysfunction

TREATMENT

% dead cells

CTRL

2 ± 1.3

Gp120 100 pM

16 ± 1.4*

Gp120 1 nM

38 ± 2*

Gp120 10 nM

45 ± 3.2*

Gp120 10 nM + NAC 0.5 mM

40 ± 2.4§

Gp120 10 nM + NAC 1 mM

22 ± 2.1§

Gp120 10 nM + NAC 5 mM

6 ± 2§

  1. P < 0.05 gp120-treated astrocytes vs control (CTRL)
  2. § P < 0.05 NAC vs gp120-treated astrocytes
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BMC Neuroscience

ISSN: 1471-2202

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