Table 1 A list of major pre-synaptic proteins in the mammalian synapse.
From: Synaptic proteins as multi-sensor devices of neurotransmission
Protein | ID UniProt | Symbol HUGOa | Localization | TMD | Commentb |
|---|---|---|---|---|---|
1. Amisyn | Q8NFX7 | STXBP6 | Cyt | No | Exo |
2. Amphyphysin | P49418 | AMPH | SV, PM | No | Endo |
3. Basoon | Q9UPA5 | BSN | Cyt | No | M |
4. Bridging integrator | O00499 | BIN1 | Cyt, SV | No | M* |
5. CAPS | Q9ULU8 | CADPS | Cyt, SV | No | Exo |
6. CASK | O14936 | CASK | Cyt | No | M. Exo |
7. CASKIN | Q8WXD9 | CASKIN1 | Cyt, PM | No | M. Exo |
8. CAST | O15083 | CAST1 | Cyt, PM | No | M |
9. Complexin | Q6PUV4 | CPLX2 | PM | No | Exo |
10. CSP | Q9H3Z4 | DNAJC5 | Cyt, SV | No | M, Exo |
11. Doc2 | DOC2A | Q14183 | SV | No | Exo |
12. Dynamin | P50570 | DNM2 | Cyt, SV | No | M, Endo |
13. Epsin | Q9Y6I3 | EPN1 | Cyt | No | M, Endo |
14. Hrs-2 | O14964 | HGS | Cyt, SV | No | M |
15. Intersectin | Q15811 | ITSN1 | CytSV | NoNo | Endo, M |
16. Latrophilin | O94910 | LPHN1 | PM | Yes | Exo |
17. Liprin-α | Q13136 | PPFIA1 | Cyt | No | M* |
18. Mint/X -11 | Q02410 | APBA1 | Cyt | No | M, Exo |
19. Munc-13 | Q9UPW8 | UNC13A | Cyt, PM | No | M, Exo -Endo |
20. Munc-18 | O00186 | STXBP3 | Cyt, PM | No | Exo |
21. Neurexin | P58400 | NRX1 | PM | Yes | M, Exo |
22. NSF | NSF | P46459 | SV, Cyt | No | M* |
23. NT transporter | P23975 | SLC6A2 | SVPM | Yes | M |
24. NTvesicle transporter | Q16572 | SLC18A3 | PMSV | Yes | M |
25. P/Q Ca2+ channel | O00555 | CACNA1A | PM | Yes | Exo |
26. Pallklin | Q9UL45 | PLDN | Cyt, SV | No | M |
27. Piccolo | Q9Y6VO | PCLO | Cyt | No | M |
28. Rab3 | P20336 | RAB3A | Cyt, SV | No | M, Exo * |
29. Rabconnectin-3 | Q8WTV7 | DMXL2 | Cyt | No | M, Exo |
30. Rabphilin | Q9Y2JO | RPH3A | SV | No | M, Exo |
31. RIM | Q86UR5 | RIMS1 | PM | No | M, Exo |
32. RIMS binding protein | O15034 | RIMBP2 | SV | Yes | Exo, M * |
33. SCAMP | O15126 | SCAMP1 | SV | Yes | M |
34. SNAP-25 | P60880 | SNAP25 | PM | No | Exo |
35. Snapin | O95295 | SNAPAP | PM, Cyt | No | Exo, Endo |
36. Stonin-2 | Q8WXE9 | STN2 | Cyt | No | Endo |
37. SV2 | Q7L0J3 | SV2A | SV | Yes | Exo, M |
38. Synapsin | P17600 | SYN1 | SV | No | M |
39. synaptogyrin | O43759 | SYNGR1 | SV | Yes | Exo |
40. Synaptojanin | O43426 | SYNJ1 | Cyt PM | No | Endo* |
41. Synaptophysin | P08247 | SYP | SV | Yes | M, Exo |
42. Synaptotagmin | P21579 | SYT1 | SV | Yes | Exo, Endo |
43. Syntaphilin | O15079 | SNPH | PM | Yes | Exo |
44. Syntaptoporin | Q8TBG9 | SYNPR | PM | Yes | Exo |
45. Syntaxin | Q16623 | STX1A | PM | Yes | Exo |
46. Tomosyn | Q5T5C0 | STXBP5 | PM | Yes | Exo |
47. VAMP | P63027 | VAMP1 | SV | Yes | Exo |
48. VAT-1 | Q99536 | VAT1 | SV | No | M |
49. Vo | P27449 | ATP6V0C | PM | Yes | Exo, Endo |
50. α-SNAP | P54920 | NAPA | SV | No | M, Exo |