Figure 6

Potential editing site complementary sequence (ECS) in intron 4 of the synapsin gene and predicted folding of the pre-mRNA. (A) Genomic sequence of synapsin, exon 4 is underlined. Bases belonging to the codons for the two arginines in the protein kinase target motif are shown as capital letters, the edited adenosine is bold. The potential ECS is marked by the broken line in the sequence of intron 4. (B) Secondary structure of 250 bases of pre-mRNA of synapsin surrounding the editing site as predicted by the computer program MFOLD [35]. Capital and bold letters as in A.