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Table 1 Dose response relationships for antipsychotic drug-induced changes in the expression of SREBP target genes

From: Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: Marked differences between various antipsychotic drugs

 

HMGCR

HMGCS1

SC5DL

LDLR

chlorpromazine

    

0.1 μM

0.8 ± 0.1

1.0 ± 0.1

1.0 ± 0.09

1.0 ± 0.05

1.0 μM

1.2 ± 0.1

1.8 ± 0.2*

1.2 ± 0.1

1.7 ± 0.3*

10 μM

2.3 ± 0.03***

3.5 ± 0.3***

1.4 ± 0.1***

1.3 ± 0.05*

25 μM

2.6 ± 0.2***

2.3 ± 0.1**

1.3 ± 0.07**

1.0 ± 0.3

haloperidol

    

0.1 μM

1.0 ± 0.06

1.1 ± 0.1

1.2 ± 0.02

1.1 ± 0.03

1.0 μM

1.3 ± 0.2

1.7 ± 0.3

1.5 ± 0.1**

1.5 ± 0.1

10 μM

2.7 ± 0.2***

4.1 ± 0.5**

3.3 ± 0.07***

2.3 ± 0.2***

25 μM

3.2 ± 0.3***

3.8 ± 0.8*

3.4 ± 0.2***

2.8 ± 0.3***

clozapine

    

0.1 μM

1.1 ± 0.06

1.1 ± 0.03

1.0 ± 0.01

1.1 ± 0.02

1.0 μM

1.2 ± 0.1

1.0 ± 0.01

1.0 ± 0.02

1.2 ± 0.08

10 μM

1.8 ± 0.3*

3.3 ± 0.2***

1.9 ± 0.1*

1.7 ± 0.2**

25 μM

2.5 ± 0.1***

5.2 ± 0.6***

2.8 ± 0.4***

2.3 ± 0.3***

olanzapine

    

0.1 μM

0.9 ± 0.03

0.9 ± 0.09

0.8 ± 0.03

1.0 ± 0.1

1.0 μM

1.0 ± 0.1

1.6 ± 0.3

0.9 ± 0.06

1.0 ± 0.05

10 μM

1.2 ± 0.1

1.7 ± 0.2

1.2 ± 0.09

1.3 ± 0.1

25 μM

2.5 ± 0.3*

3.6 ± 0.04***

1.8 ± 0.3**

2.2 ± 0.3**

risperidone

    

0.1 μM

0.8 ± 0.05

0.9 ± 0.1

0.8 ± 0.01

0.9 ± 0.05

1.0 μM

0.9 ± 0.1

1.0 ± 0.1

0.9 ± 0.01

1.0 ± 0.08

10 μM

1.2 ± 0.07

1.2 ± 0.05

1.1 ± 0.09

1.2 ± 0.1

25 μM

1.7 ± 0.09**

1.8 ± 0.09

1.6 ± 0.2

1.5 ± 0.07

ziprasidone

    

0.1 μM

1.1 ± 0.02

1.1 ± 0.05

1.2 ± 0.04

1.1 ± 0.03

1.0 μM

1.1 ± 0.02

1.1 ± 0.1

1.2 ± 0.1

1.1 ± 0.03

10 μM

1.4 ± 0.04*

1.5 ± 0.05*

1.5 ± 0.2

1.3 ± 0.04

25 μM

1.5 ± 0.08*

1.3 ± 0.08*

1.7 ± 0.03**

1.5 ± 0.04

  1. The expression levels of HMGCR, HMGCS1, SC5DL and LDLR were measured by quantitative RT-PCR in cultured GaMg glioma cells, determined relative to the expression of the ribosomal gene P0. The fold change is given relative to the vehicle-treated control. The statistical significance was denoted as follows: *p < 0.05, **p < 0.01, ***p < 0.001. The fold changes (mean ± SEM) are representative of three independent parallel experiments and measured relative to vehicle treated control