HMGCR | HMGCS1 | SC5DL | LDLR | |
---|---|---|---|---|
chlorpromazine | ||||
0.1 μM | 0.8 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.09 | 1.0 ± 0.05 |
1.0 μM | 1.2 ± 0.1 | 1.8 ± 0.2* | 1.2 ± 0.1 | 1.7 ± 0.3* |
10 μM | 2.3 ± 0.03*** | 3.5 ± 0.3*** | 1.4 ± 0.1*** | 1.3 ± 0.05* |
25 μM | 2.6 ± 0.2*** | 2.3 ± 0.1** | 1.3 ± 0.07** | 1.0 ± 0.3 |
haloperidol | ||||
0.1 μM | 1.0 ± 0.06 | 1.1 ± 0.1 | 1.2 ± 0.02 | 1.1 ± 0.03 |
1.0 μM | 1.3 ± 0.2 | 1.7 ± 0.3 | 1.5 ± 0.1** | 1.5 ± 0.1 |
10 μM | 2.7 ± 0.2*** | 4.1 ± 0.5** | 3.3 ± 0.07*** | 2.3 ± 0.2*** |
25 μM | 3.2 ± 0.3*** | 3.8 ± 0.8* | 3.4 ± 0.2*** | 2.8 ± 0.3*** |
clozapine | ||||
0.1 μM | 1.1 ± 0.06 | 1.1 ± 0.03 | 1.0 ± 0.01 | 1.1 ± 0.02 |
1.0 μM | 1.2 ± 0.1 | 1.0 ± 0.01 | 1.0 ± 0.02 | 1.2 ± 0.08 |
10 μM | 1.8 ± 0.3* | 3.3 ± 0.2*** | 1.9 ± 0.1* | 1.7 ± 0.2** |
25 μM | 2.5 ± 0.1*** | 5.2 ± 0.6*** | 2.8 ± 0.4*** | 2.3 ± 0.3*** |
olanzapine | ||||
0.1 μM | 0.9 ± 0.03 | 0.9 ± 0.09 | 0.8 ± 0.03 | 1.0 ± 0.1 |
1.0 μM | 1.0 ± 0.1 | 1.6 ± 0.3 | 0.9 ± 0.06 | 1.0 ± 0.05 |
10 μM | 1.2 ± 0.1 | 1.7 ± 0.2 | 1.2 ± 0.09 | 1.3 ± 0.1 |
25 μM | 2.5 ± 0.3* | 3.6 ± 0.04*** | 1.8 ± 0.3** | 2.2 ± 0.3** |
risperidone | ||||
0.1 μM | 0.8 ± 0.05 | 0.9 ± 0.1 | 0.8 ± 0.01 | 0.9 ± 0.05 |
1.0 μM | 0.9 ± 0.1 | 1.0 ± 0.1 | 0.9 ± 0.01 | 1.0 ± 0.08 |
10 μM | 1.2 ± 0.07 | 1.2 ± 0.05 | 1.1 ± 0.09 | 1.2 ± 0.1 |
25 μM | 1.7 ± 0.09** | 1.8 ± 0.09 | 1.6 ± 0.2 | 1.5 ± 0.07 |
ziprasidone | ||||
0.1 μM | 1.1 ± 0.02 | 1.1 ± 0.05 | 1.2 ± 0.04 | 1.1 ± 0.03 |
1.0 μM | 1.1 ± 0.02 | 1.1 ± 0.1 | 1.2 ± 0.1 | 1.1 ± 0.03 |
10 μM | 1.4 ± 0.04* | 1.5 ± 0.05* | 1.5 ± 0.2 | 1.3 ± 0.04 |
25 μM | 1.5 ± 0.08* | 1.3 ± 0.08* | 1.7 ± 0.03** | 1.5 ± 0.04 |