Figure 1

Inhibition of prefrontal protein synthesis following recall of a one-day trace fear conditioning paradigm does not disrupt memory. A, Scheme illustrating the chronology of training (CS-US), reactivation 24 hours later, intra-mPFC infusion, and retention testing in a novel context two days following the infusions. B, Graph of the mean percent freezing ± standard error of the mean (SEM) before CS presentation, during CS presentation, and during the trace period of the reactivation trial. Animals were infused with 2 ul of either anisomycin or vehicle directly into the mPFC, immediately following the reactivation trial. C, Graph of the mean ± SEM percent freezing before CS presentation, to the CS, and during the trace period of the retention testing trials for intra-mPFC anisomycin- and vehicle-infused groups, expressed as an average of four trials.