Figure 2
From: Isoflurane depresses hippocampal CA1 glutamate nerve terminals without inhibiting fiber volleys
Depressant actions on FV-EPSP relations. A, (Left) Isoflurane (350 μM; 1.5 vol %) reduced EPSP amplitudes over a range of stimulus levels. Control responses are shown in black and isoflurane-depressed EPSPs are in blue. (Right) Isoflurane reduced the slope of the FV-EPSP relation (blue circles). B, (Left) EPSP amplitudes were strongly decreased when external Ca2+ was reduced from 2 mM to 0.8 mM. (Right) slope of the FV-EPSP relation was reduced by 0.8 mM Ca2+ (blue circles). C, (Left) reduction of EPSP and FV amplitudes by tetrodotoxin (TTX; 60 nM). (Right) no change in the FV-EPSP relation in the presence of TTX. All FV-EPSP relations were well fit by single exponential functions.