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Table 3 Effects of inhibitors of caspases 3, 8 and 9 against toxicity and ROS accumulation after serum deprivation in enriched hippocampal neuronal cultures, as estimated by MTT and DCF assays, respectively.

From: Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation

Drugs MTT values (% of control) DCF values (% of control)
Control 100 ± 4 100 ± 6
   + Inhibitor of caspase 3 (DEVDO-CHO, 5 μM) 171 ± 12 * 85 ± 4
   + Inhibitor of caspase 8 (IETD-CHO 5 μM) 141 ± 9 * 96 ± 5
   + Inhibitor of caspase 9 (LEHD-CHO, 5 μM) 135 ± 10 * 89 ± 6
   + Clozapine (1 μM) 140 ± 8 * ND
  1. Data represent mean ± SEM of at least three separate experiments. *p < 0.01 compared to vehicle-treated cells. ND: not determined