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Table 2 Effects of NE-100, (+)-MK-801 and of a co-treatment of raclopride with clozapine in enriched hippocampal neuronal cultures, as estimated by the MTT and NR assays

From: Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation

Drugs MTT (% of control) NR (% of control)
Control 100 ± 6 ND
   + N2 177 ± 10 ND
   + Raclopride (10-6 M) 103 ± 5 ND
   + Clozapine (10-6 M) 199 ± 13 ND
   + Raclopride (10-6 M) + Clozapine (10-6 M) 117 ± 8 ND
Control 100 ± 6 100 ± 4
   + NE-100 (10-7 M) 97 ± 6 93 ± 3
   + NE-100 (10-6 M) 112 ± 9 95 ± 4
   + NE-100 (10-5 M) 127 ± 9 82 ± 5*
Control 100 ± 5 100 ± 8
   + (+)-MK-801 (10-6 M) 123 ± 9 128 ± 6
   + (+)-MK-801 (10-5 M) 130 ± 12 112 ± 14
  1. Data represent mean ± SEM of at least three separate experiments. *p < 0.01, control versus drugs-treated cells. p < 0.01, cells treated with clozapine alone versus cells co-treated with raclopride and clozapine. ND: not determined.