Table 2 Effects of NE-100, (+)-MK-801 and of a co-treatment of raclopride with clozapine in enriched hippocampal neuronal cultures, as estimated by the MTT and NR assays
Drugs | MTT (% of control) | NR (% of control) |
|---|---|---|
Control | 100 ± 6 | ND |
+ N2 | 177 ± 10 | ND |
+ Raclopride (10-6 M) | 103 ± 5 | ND |
+ Clozapine (10-6 M) | 199 ± 13 | ND |
+ Raclopride (10-6 M) + Clozapine (10-6 M) | 117 ± 8¶ | ND |
Control | 100 ± 6 | 100 ± 4 |
+ NE-100 (10-7 M) | 97 ± 6 | 93 ± 3 |
+ NE-100 (10-6 M) | 112 ± 9 | 95 ± 4 |
+ NE-100 (10-5 M) | 127 ± 9 | 82 ± 5* |
Control | 100 ± 5 | 100 ± 8 |
+ (+)-MK-801 (10-6 M) | 123 ± 9 | 128 ± 6 |
+ (+)-MK-801 (10-5 M) | 130 ± 12 | 112 ± 14 |