Table 3 Efficacy of select estrogens within CEE to reduce LDH release following exposure to excitotoxic glutamate in basal forebrain neurons. Neuronal cultures were pretreated with indicated estrogens for 4 days followed by a 5 min exposure to 200 μM glutamate. The culture medium was replaced and cultures were allowed to incubate for an additional 24 hr followed by determination of LDH release into the medium. Data are represented as mean ± SEM (n = 11 – 14 from 3 experiments). ** P < 0.01 and *** P < 0.001 compared to glutamate alone-treated cultures.