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Table 2 Efficacy of select estrogens within CEE to sustain the intracellular ATP level following exposure to β-amyloid25–35 in basal forebrain neurons. Neuronal cultures were pretreated with indicated estrogens for 4 days followed by a 24 hr exposure to 8 μg/ml β-amyloid25–35. The culture medium was replaced and cultures were allowed to incubate for an additional 24 hr followed by determination of the intracellular ATP level. Data are represented as mean ± SEM (n = 7 – 24 from 3 separate experiments). ** P < 0.01 and *** P < 0.001 compared to β-amyloid25–35 alone-treated cultures.

From: Select estrogens within the complex formulation of conjugated equine estrogens (Premarin®) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease

Treatment (pg/ml) ATP Level (% of β-amyloid25–35 alone group)
Control 203.37 ± 11.67***
β-amyloid25–35 alone 100.00 ± 2.07
17α-estradiol (10) 103.83 ± 3.76
17β-estradiol (10) 131.32 ± 4.56**
Equilin (1000) 114.58 ± 3.56
Equilenin (300) 96.44 ± 4.07
17α-dihydroequilin (1000) 110.00 ± 2.75
17β-dihydroequilin (40) 110.75 ± 2.46
Estrone (5000) 128.84 ± 4.14**
Δ8,9-dehydroestrone (300) 125.05 ± 1.42**