Gene transfer of constitutively active ERK and AKT protect cells from gp120 toxicity (A) After gene transfer of constitutively active (ca) ERK or ca AKT, HUVEC were exposed to gp120, FGF2 or a combination of both and cell viability was assayed via Trypan Blue Exclusion. Controls consisted of ca ERK, ca AKT and GFP gene transfer without further treatment. * indicates a significant difference from control. ** indicates a significant difference from *. * = P < 0.05 by One-Way ANOVA with post-hoc Dunnett's when compared to control. ** = P < 0.05 by One-Way ANOVA with post-hoc Tukey-Kramer when compared between experimental groups.