Figure 6
From: Astrocyte reactivity to Fas activation is attenuated in TIMP-1 deficient mice, an in vitrostudy
The effect of astrocytes on lymphocyte migration was assessed using Transwell chambers and was expressed by the total number of migrated cells (A) and as an index of migration (B). Note that anti-Fas treatment alone without astrocytes in the lower compartment induced lymphocyte migration. Only KO astrocytes treated with TNF-α induced significant lymphocyte migration. Values represent the mean +/- s.e.m. of at least three independent experiments. Statistical differences were determined by Student's t-test when comparing treatments to control cells (* p < 0.05) or astrocytes vs no astrocyte (● p < 0.05).