Figure 5

Electrophysiological recordings demonstrating the interaction between MCEPH and Kv1.2 and Kv1.3 in Xenopus oocytes. A. Currents of Kv1.2 and Kv1.3, when expressed separately and when coexpressed with MCEPH in Xenopus oocytes. Pulse steps from -80 to +50 mV (increment between the steps 10 mV), followed by a step to +30 to enable measurements of the inactivation. B. Activation curves (peak conductance versus voltage) for Kv1.2 and Kv1.3, when expressed separately and when coexpressed with MCEPH. Same stimulation protocols as in A. Error bars mark standard error of mean. C. Inactivation curves (normalized peak conductance, associated with the second pulse, versus voltage of preceding step; see panel A) for Kv1.2 and Kv1.3, when expressed separately and when coexpressed with MCEPH. Same stimulation protocols as in A. Error bars mark standard deviation.