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Figure 6 | BMC Neuroscience

Figure 6

From: The neurotrophin receptor p75NTR mediates early anti-inflammatory effects of estrogen in the forebrain of young adult rats

Figure 6

PGE 2 levels in the lesioned olfactory bulb: PGE2 expression was not altered by lesion or hormone treatment at 6 h post injury (6 hpi). However, at 24 hpi, PGE2 expression increased 2-fold in the control-pellet (OVX) replaced lesioned groups, while this increase was not seen in the estrogen-treated (OVX+E) lesioned animals. However, anti-p75NTR treatment completely abolished estrogen's suppressive effects, making this group indistinguishable from the control pellet replaced, lesioned animals. Bars represent means ± SEM, n = 6 per group. Sham: Sham lesion, Lesion+Vehicle: NMDA injection with pre immune serum, Lesion+Anti p75: NMDA injections with anti-p75NTR antibodies. *:p < 0.05.

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