Figure 2

Changing lin-12 activity in adults alters spontaneous reversal rates. Changing lin-12 activity in adults alters spontaneous reversal rates. A. Reversal rate changes in hsp::lin-12(RNAi) animals. Filled triangles indicate hsp::lin-12(RNAi) animals; filled circles indicate wild type control animals; and open squares indicate hsp::grk-2(RNAi) control animals. Animals were heat shocked at 33°C for 2 hours, allowed to recover at 25°C then tested 4 hours later. After recovery at 25°C overnight (approx. 16 hours), animals were tested again. *** p<0.001 vs. wild type. B. Reversal rate changes in lin-12(gfcs) animals. lin-12(gfcs) animals raised at the permissive temperature (25°C) are indicated by open squares, and those raised at the restrictive temperature (15°C) by filled squares. Open and filled circles indicate wild type animals raised at 25 and 15°C, respectively. Temperature shifts from 25 to 15°C are indicated by solid lines, and those from 15 to 25°C are indicated by dotted lines. * p<0.01 vs. t = 0 hrs.; ** p<0.01 vs. t = 4 hrs.; *** p<0.001 vs. t = 0 hrs.