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Table 2 Lamina cribrosa cell and ONH astrocyte responses to oxygen-glucose deprivation.

From: Neurotrophin and Trk expression by cells of the human lamina cribrosa following oxygen-glucose deprivation

  Lamina cribrosa cells ONH astrocytes
Cell Number 95 % survival at 24 hrs, 85% at 48 hrs 70 % survival at 24 hrs, 80% at 48 hrs
NT Expression ↑ NGF, ↑ BDNF, ↑ NT-3; ↓ NT-4 ↑ BDNF, ↑ NT-3; ↓ NGF, ↓ NT-4
Trk Expression ↑ Trk A; ↓ Trk C, ↓ Trk B ↓ Trk A, ↓ Trk C, ↓ Trk B.T
Phospho-Trk Expression ↑ 120 kDa isoform (Trk A); ↓ 148 kDa isoform ↓ all phospho-trk receptors
  isoform  
Secretion of NTs ↑ NGF; ↓ BDNF ↑ NGF; ↓ BDNF