| Lamina cribrosa cells | ONH astrocytes |
---|---|---|
Cell Number | 95 % survival at 24 hrs, 85% at 48 hrs | 70 % survival at 24 hrs, 80% at 48 hrs |
NT Expression | ↑ NGF, ↑ BDNF, ↑ NT-3; ↓ NT-4 | ↑ BDNF, ↑ NT-3; ↓ NGF, ↓ NT-4 |
Trk Expression | ↑ Trk A; ↓ Trk C, ↓ Trk B | ↓ Trk A, ↓ Trk C, ↓ Trk B.T |
Phospho-Trk Expression | ↑ 120 kDa isoform (Trk A); ↓ 148 kDa isoform | ↓ all phospho-trk receptors |
 | isoform |  |
Secretion of NTs | ↑ NGF; ↓ BDNF | ↑ NGF; ↓ BDNF |