Responses to different experimental conditions in left and right lateral fusiform gyri Middle panels. Coronal view of the activation foci in the lateral fusiform gyri bilaterally. These SPMs are derived from the contrast that tested for a simple effect of changing stimulus features (see Methods) and are superimposed on an averaged T1-weighted MR image of all our subjects. Arrows are pointing to the maximally activated voxels in the region. Left and right panels. Group mean parameter estimates (regression coefficients ± s.e.m.) to each of the experimental conditions for bilateral lateral fusiform gyrus are shown. All conditions with changing stimulus features (identity, emotion; VICE, CIVE, VIVE) elicit significantly larger activation of the peak voxels in both fusiform gyri than condition CICE in which the same pictures were shown for the entire block. Asterisks (*) indicate significant differences of respective condition compared with condition CICE at the specified uncorrected significance level. Bottom left and right panels. Detailed (emotion-specific) analysis of condition VICE. Category labels refer to maximally fearful, neutral, and maximally happy facial expression. Intermediate categories are minimally fearful and minimally happy facial expression. Largest activations are elicited by maximally fearful faces. Asterisks (*) indicate significant differences between the respective emotion compared with maximally fearful faces at the specified significance level, pluses (+) indicate significant differences between the respective emotion compared with maximally happy faces at the specified uncorrected significance level.