Dipteran and mammalian parkin proteins are well conserved. (A) Schematic representation of the Drosophila melanogaster parkin transcription unit and its location in the genomic scaffolding region AE003593. (B) ClustalW alignment of the Drosophila melanogaster parkin with homologues from Anopheles gambiae, Rattus norvegicus, Mus musculus and Homo sapiens. Highlighted are the Ubiquitin-like Domain (UBL) (green box); the Unique Parkin Domain (UPD) (red box); RING1 and RING2 (blue boxes); In-Between Ring Domain (IRB) (black box). "*" and red lettering indicates amino acids that are identical in all sequences in the alignment. ":" and green lettering indicates conserved substitutions. "." and blue lettering indicates semi-conserved substitutions.