Figure 3
From: Insulin signaling inhibits the 5-HT2Creceptor in choroid plexus via MAP kinase
Effects of tyrosine kinase inhibitor and dominant-negative RAS antibody on IGF-1 effects on the serotonin response in Xenopus oocytes. Shown are peak Cl- currents in response to 5-HT after the indicated treatments. (A) Genistein, a tyrosine kinase inhibitor, blocks the inhibitory effect of IGF-1 on the 5-HT response. The data are presented as mean ± S.E.M. of 11-12 oocytes (*, P < 0.05). (B) RAS antibody, Y13-259, blocks the inhibitory effect of IGF-1 on the 5-HT response. The data are presented as mean ± S.E.M. of 6 oocytes (*, P < 0.05).