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Figure 2 | BMC Neuroscience

Figure 2

From: Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake

Figure 2

Decreasing AGRP levels with siRNA increases metabolic rate. (a) Heat production for AGRP-siRNA injected mice was found to be significantly and dramatically elevated one day following surgery compared to the control injected GFP-siRNA mice (n = 16; p < 0.0001). (b) Oxygen consumption, VO2, was also significantly elevated one day after surgery for mice injected with the AGRP-siRNA particles (n = 16; p < 0.0003).

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