A) Detectability of synaptic inputs of different strengths in a fully-defined input paradigm (data for N = 4 Layer 2/3 pyramidal cells) for 1Hz, 5Hz, and 10Hz post-synaptic firing rates. Note that detection of inputs improves with higher firing rates and that inhibitory inputs require longer recording periods than detection of excitatory inputs. Detection time for inputs of different amplitudes drops as approximately c/x2. B, left) Ground truth PSC amplitude vs the amplitude of the cross-correlation (25ms window following pre-synaptic spikes) for 5Hz post-synaptic spiking. B, right) Ground truth PSC amplitude vs the model-based coupling coefficient. Note that model-based coefficients more accurately reconstruct the true amplitudes. Dashed lines denote a linear fit, gray line denotes a 4th-order polynomial fit to account for the nonlinear relationship between PSC amplitude and correlation coefficients.