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Open Access

Inhibitory single neuron control of seizures and epileptic traveling waves in humans

  • Omar J Ahmed1Email author,
  • Mark A Kramer7,
  • Wilson Truccolo5,
  • Jason S Naftulin1,
  • Nicholas S Potter4,
  • Emad N Eskandar2,
  • Garth R Cosgrove3,
  • Andrew S Blum4,
  • Leigh R Hochberg1, 6 and
  • Sydney S Cash1
BMC Neuroscience201415(Suppl 1):F3

https://doi.org/10.1186/1471-2202-15-S1-F3

Published: 21 July 2014

Inhibitory neuronal activity is critical for the normal functioning of the brain, but is thought to go awry during neurological disorders such as epilepsy. Animal models have suggested both decreased and increased inhibition as possible initiators of epileptic activity, but it is not known if, or how, human inhibitory neurons shape seizures. Here, using large-scale recordings of neocortical single neurons in patients with secondarily generalized tonic-clonic seizures, we show that fast-spiking (FS) inhibitory activity first increases as a seizure spreads across the neocortex, impeding and altering the spatial flow of fast epileptic traveling waves. Unexpectedly, however, FS cells cease firing less than half-way through a seizure. We use biophysically-realistic computational models to show that this cessation is due to FS cells entering depolarization block as a result of extracellular potassium accumulation during the seizure and not because they are inhibited by other inhibitory subtypes. Strikingly, this absence of FS inhibitory activity is accompanied by dramatic increases in local seizure amplitude along with unobstructed traveling waves and is seen during all secondarily generalized seizures examined, independent of etiology or focus. FS cessation also leads to prominent spike-and-wave events, suggesting that FS cell dynamics control the transition between the tonic and clonic phases of these seizures. Thus, it may be possible to curtail human seizures by preventing inhibitory neurons from entering potassium-dependent depolarization block, a novel and potentially powerful therapeutic avenue in treating multiple kinds of epilepsies.

Declarations

Acknowledgements

We would like to thank the patient volunteers. This work was supported by postdoctoral fellowships from the Epilepsy Foundation (222178), MGH (2012A052031) & NINDS (F32-NS083208) awarded to OJA and by R01-NS062092 (SSC), R01-NS072023 (MAK) and R01-NS079533 (WT).

Authors’ Affiliations

(1)
Department of Neurology, Harvard Medical School and Massachusetts General Hospital
(2)
Department of Neurosurgery, Harvard Medical School and Massachusetts General Hospital
(3)
Department of Neurosurgery, Rhode Island Hospital
(4)
Department of Neurology, Rhode Island Hospital
(5)
Department of Neuroscience, Brown University
(6)
School of Engineering, Brown University
(7)
Department of Mathematics & Statistics, Boston University

Copyright

© Ahmed et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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