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Table 2 Gene Set Enrichment Analysis (GSEA) results

From: Fetal asphyctic preconditioning alters the transcriptional response to perinatal asphyxia

Time of sacrifice

Gene set name

Description

NES

FDR q-value

Direction

Experimental group

6 h

KEGG:04141

Protein processing in endoplasmatic reticulum

2.54

<0.001

PA and FAPA

 

PF01352

KRABbox

2.42

<0.001

FAPA

 

PF00956

Nucleosome assembly protein

2.14

<0.01

 
 

KEGG:00970

Aminoacyl-tRNA biosynthesis

2.47

<0.001

 
 

KEGG:00510

N-glycan biosynthesis

2.04

<0.01

 
 

KEGG:00100

Steroid biosynthesis

-2.58

<0.001

 

96 h

GO:0005746

Mitochondrial respiratory chain

-2.20

<0.01

PA and FAPA

 

KEGG:00190

Oxidative phosphorylation

-2.34

<0.001

 
 

GO:0001505

Regulation of neurotransmitter levels

-2.22

<0.01

PA

 

GO:0007268

Synaptic transmission

-2.11

<0.01

 
 

GO:0007269

Neurotransmitter secretion

-2.23

<0.01

 
 

KEGG:04020

Calcium signaling pathway

-1.97

<0.01

 
 

KEGG:04970

Salivary secretion

-2.16

<0.01

 
 

KEGG:04971

Purine metabolism

-2.04

<0.01

 
 

PF00089

Trypsin

2.23

<0.01

FAPA

 

GO:0019208

Phosphatase regulator activity

-2.09

<0.01

 
 

KEGG:03010

Ribosome

-2.237

<0.001

 
 

BIOCARTA_PGC1APATHWAY

-2.09

<0.01

 
  1. Significantly enriched gene sets found with GSEA using the FDR q-value <0.01 as cut-off for significance. NES = Normalized Enrichment Score. FDR q-value = False Discovery Rate method of correction for multiple testing. (PA: experimental group only subjected to perinatal asphyxia. FAPA: experimental group subjected to both fetal preconditioning and perinatal asphyxia).