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Table 3 Average morphometric data of the renal nerves’ myelinated and unmyelinated fibers, from the six experimental groups: acute diabetic group (15 days after STZ injection), acute treated group, acute control group, chronic diabetic group (12 weeks after STZ injection), chronic treated group and chronic control group

From: Renal nerve ultrastructural alterations in short term and long term experimental diabetes

 

Acute diabetic

Acute treated

Acute control

Chronic diabetic

Chronic treated

Chronic control

Myelinated fiber area (μm2)

14.2 ± 1.5

11.8 ± 0.8

20.8 ± 2.8°

17.8 ± 1.6°

19.6 ± 2.3°

11.1 ± 1.0

Myelinated fiber diameter (μm)

3.9 ± 0.1

3.7 ± 0.1

4.7 ± 0.3°

4.3 ± 0.2°

4.4 ± 0.3°

3.3 ± 0.1

G ratio

0.56 ± 0.01

0.55 ± 0.01

0.54 ± 0.01

0.56 ± 0.01°

0.55 ± 0.01

0.53 ± 0.01

Myelin sheath area (μm2)

8.9 ± 0.9

7.9 ± 0.51

13.9 ± 1.7+°

11.3 ± 0.9°

12.1 ± 1.3°

7.7 ± 0.6

Myelinated axon area (μm2)

5.2 ± 0.7

3.9 ± 0.4

6.9 ± 1.2°

6.4 ± 0.7°

7.5 ± 1.1°

3.5 ± 0.4

Myelinated axon diameter (μm)

2.3 ± 0.2

2.1 ± 0.1

2.6 ± 0.2°

2.5 ± 0.1°

2.5 ± 0.2°

1.8 ± 0.1

Unmyelinated axon area (μm2)

0.65 ± 0.07

0.62 ± 0.07

0.58 ± 0.03

0.57 ± 0.03

0.80 ± 0.10°#

0.56 ± 0.06

Unmyelinated axon diameter (μm)

0.76 ± 0.04

0.73 ± 0.03

0.73 ± 0.02

0.72 ± 0.02

0.83 ± 0.04°

0.68 ± 0.04

  1. +Indicates difference compared to acute treated, °indicates difference compared to chronic control, #indicates difference compared to chronic diabetic group.