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Table 3 Average morphometric data of the renal nerves’ myelinated and unmyelinated fibers, from the six experimental groups: acute diabetic group (15 days after STZ injection), acute treated group, acute control group, chronic diabetic group (12 weeks after STZ injection), chronic treated group and chronic control group

From: Renal nerve ultrastructural alterations in short term and long term experimental diabetes

  Acute diabetic Acute treated Acute control Chronic diabetic Chronic treated Chronic control
Myelinated fiber area (μm2) 14.2 ± 1.5 11.8 ± 0.8 20.8 ± 2.8° 17.8 ± 1.6° 19.6 ± 2.3° 11.1 ± 1.0
Myelinated fiber diameter (μm) 3.9 ± 0.1 3.7 ± 0.1 4.7 ± 0.3° 4.3 ± 0.2° 4.4 ± 0.3° 3.3 ± 0.1
G ratio 0.56 ± 0.01 0.55 ± 0.01 0.54 ± 0.01 0.56 ± 0.01° 0.55 ± 0.01 0.53 ± 0.01
Myelin sheath area (μm2) 8.9 ± 0.9 7.9 ± 0.51 13.9 ± 1.7+° 11.3 ± 0.9° 12.1 ± 1.3° 7.7 ± 0.6
Myelinated axon area (μm2) 5.2 ± 0.7 3.9 ± 0.4 6.9 ± 1.2° 6.4 ± 0.7° 7.5 ± 1.1° 3.5 ± 0.4
Myelinated axon diameter (μm) 2.3 ± 0.2 2.1 ± 0.1 2.6 ± 0.2° 2.5 ± 0.1° 2.5 ± 0.2° 1.8 ± 0.1
Unmyelinated axon area (μm2) 0.65 ± 0.07 0.62 ± 0.07 0.58 ± 0.03 0.57 ± 0.03 0.80 ± 0.10°# 0.56 ± 0.06
Unmyelinated axon diameter (μm) 0.76 ± 0.04 0.73 ± 0.03 0.73 ± 0.02 0.72 ± 0.02 0.83 ± 0.04° 0.68 ± 0.04
  1. +Indicates difference compared to acute treated, °indicates difference compared to chronic control, #indicates difference compared to chronic diabetic group.