Skip to main content

Table 2 Effect of soman (105 μg/kg) on c-Fos and Bax mRNA levels in different brain regions

From: Efficacy of antidotes (midazolam, atropine and HI-6) on nerve agent induced molecular and neuropathological changes

Time points Fold change over control
Hippocampus Cerebral cortex Cerebellum
Gene name c-Fos Bax c-Fos Bax c-Fos Bax
Control animals 1.0±0.18 1.0±0.21 1.0±0.24 1.0 ±0.18 1.0 ±0.16 1.0±0.13
Soman exposed       
30 min 3.50.47 2.60.13 5.0* ±0.8 2.50.24 3.00.4 0.72±0.24
2.5 h 4.20.18 1.60.31 3.10.71 2.00.3 1.8*±0.25 0.75±0.14
1 day 3.40.4 1.80.27 3.80.8 1.60.18 1.5*±0.19 0.450.18
7 day 0.65±0.3 1.50.18 0.78±0.23 1.25±0.25 0.8±0.18 0.520.09
  1. Quantitative real-time RT-PCR was carried out and results are presented as fold change over control (presented as 1.0 fold) after normalizing the data (n=4 per each time point) with housekeeping gene, RNA polymerase-II (RP-II), which did not show any significant changes in the mRNA expression among control and experimental groups (Data not presented). *Significantly different from control group. A difference of p< 0.05 was considered significant.
\