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Table 4 Summary of the variations from striatum metabolites in mice

From: 1H-Nuclear magnetic resonance-based metabolomic analysis of brain in mice with nicotine treatment

Metabolites

Chemical shift

Control-nicotine

 

(ppm)

VIPa

Loadingb

Cystine

3.36

10.51

-0.76

Glucose

3.40

5.97

-0.43

Glutamate

2.08

3.37

-0.18

Acetoacetic acid

3.44

2.02

-0.124

Tryptophan

3.48

1.92

-0.138

Lysine

1.36

1.91

±0.03

Taurine

3.28

1.54

-0.08

Creatine

3.04

1.49

±0.088

Acetylcholine

3.24

1.36

±0.054

NAA

4.4

1.36

±0.095

  1. aVariable importance in the projection (VIP ≥ 1) was obtained from OSC-PLS.
  2. bLoading: the positive (+) value represents an increase of the metabolite in the second group of the subtitle (e.g.: Control → Nicotine), while the negative(-) value represents a decrease of the metabolite in the second group of the subtitle.
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BMC Neuroscience

ISSN: 1471-2202

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