Figure 4

Effect of quetiapine on ERK1 phosphorylation in C57Bl/6 mouse striatum in the absence or presence of AG1478 (EGF receptor inhibitor) at 240 min. Representative blots (A) indicate immunoreactive bands of phosphorylated ERK (upper panel) and total ERK (lower panel) levels at 240 min following quetiapine (5 mg/kg) ± AG1478 treatment and correspond with the bar graph below. (B) Effect of AG1478 on quetiapine induced ERK1 phosphorylation at 240 min. Data are expressed relative to vehicle control standardized to 100 percent and represent the mean ± SEM of at least four mice per experimental group. *p < 0.05; **p < 0.01, statistical differences between tissue in the absence (V) and presence of quetiapine and quetiapine in the absence and presence of AG1478 are indicated. V = Vehicle, Quet = Quetiapine.