Volume 14 Supplement 1

Abstracts from the Twenty Second Annual Computational Neuroscience Meeting: CNS*2013

Open Access

Dynamics of two-process astrocyte networks

BMC Neuroscience201314(Suppl 1):P433

https://doi.org/10.1186/1471-2202-14-S1-P433

Published: 8 July 2013

Computation in the brain is often thought of as being carried out solely by neurons without regards to their supporting cells. Recent work suggests that astrocytes may play a role alongside neurons in information processing. We investigated what types of spatio-temporal patterning can be supported for such a network. Namely the astrocyte networks contained both fast speed direct connections, representing gap junction coupling, and slower speed extracellular connections, representing local ATP diffusion or changes in local potassium concentration. We investigated what spatio-temporal dynamics results from the interplay between these two processes. We observed each process individually drive network activity and saw competition between the local and direct connections.

Declarations

Acknowledgements

This work was supported by NSF CMMI 1029388 (MZ), NSF PoLS 1058034 (MZ)

Authors’ Affiliations

(1)
Physics, Univ. of Michigan
(2)
Biophysics, Univ. of Michigan

Copyright

© Maruyama and Zochowski; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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