Background
Rhythmic activity in the brain has been known since Berger's discovery of the alpha rhythm in the 1920's. Numerous mechanisms have been proposed for various rhythms but in the past half-century no consensus has been reached on the mechanism of any major rhythm. The recent development of high-throughput imaging methods enable us for the first time to rigorously and quantitatively test ideas about the dynamics of brain rhythms.
The aim of this project is to characterize the contributions of intrinsic dynamics of brain regions and network connections in generating the global dynamics of cortical activity using a mouse model.