Conclusions
We propose TVB as a novel computing tool for large-scale brain simulations. TVB is the solution to tackle systematic parameter space exploration, allowing to rapidly gain insights of the full brain dynamics repertoire as a function of structure. It moves away from the investigation of isolated regional responses and considers the function of each region in terms of the interplay among brain regions. Full brain simulations open the possibility for the exploration of the consequences of pathological changes in the system, enabling us to identify and potentially counteract those unfavorable processes.
Schematic representation of a brain network model in TVB. Together, the cortical surface and its local connectivity, the connectivity matrix and the neural mass models at the network nodes define The Virtual Brain. Additionally, stimulation patterns can be applied during simulations. Output time-series correspond to commonly used neuroimaging recordings such as EEG, MEG and BOLD.