Compound | Kd(nM) | T1/2ON (min) | KON(mol-1 · min-1) | T1/2OFF (min) | KOFF(min-1) |
---|---|---|---|---|---|
Almorexant | 0.048 | 162a | 1.58 × 107 | 268 | 2.696 × 10-3 |
Suvorexant | 0.401 | 80.1 | 7.63 × 106 | 89.4 | 7.784 × 10-3 |
DORA-12 | 0.157 | 57.5 | 2.77 × 107 | 232 | 3.154 × 10-3 |
MK-6096 | 0.338 | 62.9 | 1.69 × 107 | 118 | 6.754 × 10-3 |
DORA-22 | 0.834 | 24.7 | 9.19 × 106 | 37.8 | 1.878 × 10-2 |
SB-649868 | 0.163 | 37.0 | 2.56 × 107 | 57.0 | 1.258 × 10-2 |