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Figure 4 | BMC Neuroscience

Figure 4

From: Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation

Figure 4

Examination of the relationships between AMPA/KA receptors, ROS and WDR35. Rats were administered glutamate receptor antagonists (3 mg/kg, i.p.) or edaravone (10 mg/kg, i.p.) at 1 hour before intraperitoneal administration of DA. WDR35 protein expression at 24 hours after DA administration in hippocampal samples from rats pretreated with (A) NBQX (AMPA/KA receptor antagonist), (B) MK-801 (NMDA receptor antagonist), or (C) edaravone (Ed, radical scavenger) was analyzed by western blotting. *P < 0.05, **P < 0.01 and ***P < 0.001 (n = 4).

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BMC Neuroscience

ISSN: 1471-2202

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