Early treatment with the MEK1/2 inhibitor U0126 prevents delayed neurological deficits after SAH. Rotating pole scores obtained at 1, 2 and 3 days after surgery for sham-operated rats and SAH rats with prolonged acute CBF drops treated with U0126 or vehicle. All data are means ± s.e.m. Stars indicate significant differences between sham-operated rats and SAH rats treated with vehicle as determined by one-way ANOVA. ***: p < 0.001. Crosses indicate significant differences between SAH rats treated with vehicle and U0126, respectively, as determined by one-way ANOVA. +: p < 0.05, ++:p < 0.01.