Figure 3From: Early events triggering delayed vasoconstrictor receptor upregulation and cerebral ischemia after subarachnoid hemorrhageDuration of acute CBF drop during SAH determines degree of delayed upregulation of contractile receptors in cerebral arteries. (A) Contractile responses induced by 63 mM K+ in middle cerebral arteries (MCA) and basilar arteries (BA) for sham-operated rats and SAH rats with short and prolonged acute CBF drops. Data are mean ± s.e.m. of maximal K+-induced contractions for each vessel segment. (B and C) Concentration-contraction curves for basilar arteries stimulated with cumulative doses of ET-1 (B) or 5-CT (C). Shown are data obtained at 3 days after surgery in sham-operated rats, SAH-induced rats with short acute CBF drop and SAH-induced rats with prolonged acute CBF drops. Data are mean ± s.e.m as percent of 63 mM K+-induced contraction. Stars indicate significant differences between sham and SAH-induced animals as determined by two-way ANOVA (***: p < 0.001). Crosses indicate significant differences between SAH-induced rats with short and prolonged acute CBF drop, respectively, as determined by two-way ANOVA (+++: p < 0.001).Back to article page