Visualization of leukocyte-endothelium interaction at 1 day post infection with HSV-1. WT (n = 6) and CCR5-/- (n = 6) were intracerebrally inoculated with 104 PFU of HSV-1. Intravital microscopy was used to assess rolling (A) and adhesion (B) of leukocytes on the brain microvasculature, at 1 dpi. Data indicate mean ± SD of cells per minutes (A) and 100 mm (B). Intravital microscopy revealed a significant increase in leukocyte adhesion in CCR5-/- infected mice at 1 dpi (***p < 0.001). Statistical analysis used: one-way ANOVA with Tukey correction.