Figure 1From: Wild-type but not mutant SOD1 transgenic astrocytes promote the efficient generation of motor neuron progenitors from mouse embryonic stem cellsMotor neuron development in embryonic mouse neural tube. Fluorescence images of embryonic (E10.5) mouse neural tube, after immunolabelling for Olig2 (green), Islet1 (red), Hb9/MNR2 (red), Ki67 (green) and DAPI for nuclei (blue). Scale bars 50 μm. The schematic of the neural tube shows the dorsal (d1-d6) and ventral domains (v0-v3, MN) of the neural tube and corresponding expression markers. RP: roof plate, FP: floor plate, VZ: ventricular zone, MZ: mantle zone, d: dorsal, v: ventral, MN: motor neuron. Olig2+ cells are restricted to the VZ, the region of proliferating progenitor cells in the developing neural tube. Islet1+ and Hb9/MNR2+ cells are found at the peripheral mantle zone of the neural tube representing post-mitotic neurons. A small number of Olig2+/Hb9+ cells, or Olig2+/Islet1+ cells represent progenitor cells that are making the transition towards Hb9/MNR2+ neurons as they migrate away from the medial VZ to the peripheral MZ.Back to article page