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Figure 8 | BMC Neuroscience

Figure 8

From: The effects of different doses of estradiol (E2) on cerebral ischemia in an in vitro model of oxygen and glucose deprivation and reperfusion and in a rat model of middle carotid artery occlusion

Figure 8

Nissl staining showed the morphologic changes of neurons in the ischemic penumbra after MCAO. (A) Representative photographs showing neuronal damage in the ischemic penumbra after MCAO. (B) The number of injured neurons in the OVX group was significantly more than that in the control group (**p < 0.01). Treatment with 6 μg/kg or 20 μg/kg E2 significantly reduced neuronal damage and preserved morphology (#p < 0.05, v.s. OVX group). However, treatment with 50 μg/kg E2 significantly induced neuronal damage (**p < 0.05 v.s. the control group and 6 μg/kg or 20 μg/kg E2 replacement group). Scale bar: 20 μm.

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BMC Neuroscience

ISSN: 1471-2202

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