Figure 3

Behaviour. A. Rotarod: no effect of genotype on rotarod performance was detected one week pre- or post-grafting. However, a significant impairment was evident in R6/2 mice at 3 and 5 weeks post-grafting which was not improved through the implantation of undifferentiated or differentiated cells. B. Open field: the total exploratory activity of R6/2 was reduced compared to WT controls at all time points tested. Neither undifferentiated, nor differentiated, cells attenuated the deterioration of R6/2 exploratory behaviour. C. Grip strength: all R6/2 mice showed significantly impaired performance compared to WT mice at all time points. No beneficial effect of treatment was evident. (* p < 0.05, **p < 0.01, and ***p < 0.001).