Figure 4
From: Mechanisms of constitutive and ATP-evoked ATP release in neonatal mouse olfactory epithelium
Constitutive exocytotic release induces proliferation in the mouse OE. (A) Quantification of the number of BrdU-immunoreactive cells in the mouse OE and in the apical region of olfactory epithelium (apical OE) 3 days following intranasal instillation with saline (Control) or Clostridium difficile toxin A (Toxin A; 1 nM). *, p < 0.001 v. control using one-way ANOVA with Bonferroni’s planned comparison test. n = 15 and 17 sections from 3 and 4 animals for control and toxin A, respectively. (B-C) Representative BrdU immunoreactivity (green) in OE turbinates exposed to saline control (B) or Toxin A (C). Apical region is oriented to the top and the dashed white line represents the basement membrane. Scale bar is 20 μm.