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Table 1 Effects of 10 μM CCh, 1 μM atropine alone, or co-application of CCh and atropine as indicated on the maximal amplitude of the field potentials, the maximal amplitude of EPSP (EPSP max ), the I 50 and slope factor of the EPSP input–output curve

From: Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex

 

Ctl (n = 7)

CCh (n = 7)

CCh + atro (n = 7)

Field max (mV)

−0.53 ± 0.17

−0.16 ± 0.05 (*)

−0.61 ± 0.15 (+)

EPSP max (mV)

18.8 ± 1.6

11.8 ± 1.6 (*)

19.1 ± 2.2 (+)

I 50 (V)

7.25 ± 1.15

8.36 ± 1.11 (*)

6.39 ± 1.13 (+)

Slope factor

1.44 ± 0.41

2.75 ± 0.2 (*)

1.26 ± 0.43 (+)

 

Ctl (n = 7)

atro (n = 7)

atro + CCh (n = 7)

Field max (mV)

−0.63 ± 0.16

−0.73 ± 0.2 (*)

−0.78 ± 0.21 (*)

EPSP max (mV)

21 ± 1.7

21 ± 1.8

21.8 ± 1.9

I 50 (V)

9.77 ± 0.78

9.5 ± 0.8

8.92 ± 0.62

Slope factor

2.12 ± 0.36

2.05 ± 0.29

2.26 ± 0.12

  1. The order of two drugs given in the figures indicates the sequence of application (i.e. “CCh + atro” means atropine was added to a CCh containing ACSF and vice versa)
  2. These experiments were performed in STRC
  3. *: p < 0.05 vs. control, +: p < 0.05 vs. previous condition