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Table 1 Effects of 10 μM CCh, 1 μM atropine alone, or co-application of CCh and atropine as indicated on the maximal amplitude of the field potentials, the maximal amplitude of EPSP (EPSP max ), the I 50 and slope factor of the EPSP input–output curve

From: Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex

  Ctl (n = 7) CCh (n = 7) CCh + atro (n = 7)
Field max (mV) −0.53 ± 0.17 −0.16 ± 0.05 (*) −0.61 ± 0.15 (+)
EPSP max (mV) 18.8 ± 1.6 11.8 ± 1.6 (*) 19.1 ± 2.2 (+)
I 50 (V) 7.25 ± 1.15 8.36 ± 1.11 (*) 6.39 ± 1.13 (+)
Slope factor 1.44 ± 0.41 2.75 ± 0.2 (*) 1.26 ± 0.43 (+)
  Ctl (n = 7) atro (n = 7) atro + CCh (n = 7)
Field max (mV) −0.63 ± 0.16 −0.73 ± 0.2 (*) −0.78 ± 0.21 (*)
EPSP max (mV) 21 ± 1.7 21 ± 1.8 21.8 ± 1.9
I 50 (V) 9.77 ± 0.78 9.5 ± 0.8 8.92 ± 0.62
Slope factor 2.12 ± 0.36 2.05 ± 0.29 2.26 ± 0.12
  1. The order of two drugs given in the figures indicates the sequence of application (i.e. “CCh + atro” means atropine was added to a CCh containing ACSF and vice versa)
  2. These experiments were performed in STRC
  3. *: p < 0.05 vs. control, +: p < 0.05 vs. previous condition