Figure 2
From: Inhibition of SLPI ameliorates disease activity in experimental autoimmune encephalomyelitis
SLPI protein vaccination protects against adoptive transfer EAE in mice and active EAE in rats. A: SJL/J mice were vaccinated twice with SLPI or OVA and aluminum hydroxide. Six weeks after the last vaccination, EAE was induced by i.p. injection of encephalitogenic PLP specific LNC. Data are representative of two independent experiments and are shown as mean ± S.E. of the mean. The differences between the SLPI and the control group were statistically significant throughout the whole experiment after day 18 (Mann- Whitney rank sum test, p < 0.05). B: DA rats were vaccinated twice with SLPI- or OVA-protein and aluminum hydroxide. Six weeks after the last vaccination, EAE was induced by immunization with recombinant MOG protein. Data are representative of two experiments and are shown as mean ± S.E. of the mean. The differences between the SLPI and the control group were statistically significant on days 15 and 16 after disease induction as well as after day 25 (Mann-Whitney rank sum test, *, p < 0.05)