Figure 2

Laminar distribution and graphic representations of quantitative data of astrocytes in the CA1 hippocampal field. (A): Photomicrographs of CA1 layers in hippocampal sections from 3-, 6- and 18-month-old SD and HD mice. These sections were representative of mice that had astrocyte levels that were close to the mean values for each group. (B): The mean number and standard errors (s.e.m.) of stereological estimates of the total number of astrocytes for each CA1 layer in mice of the indicated age. (*) = Statistically significant differences (two tailed t-test; p < 0.05) between HD and SD age-matched mice. (#) = Statistically significant differences between SD and HD mice of different ages. LacMol. = stratum lacunosum-moleculare; Rad = stratum radiatum; Py = stratum pyramidale; Or = stratum oriens; HD = hard diet; SD = soft diet; 3 M, 6 M and 18 M indicate 3-month-old, 6-month-old and 18-month-old mice, respectively. Scale bar = 25 μm