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Table 7 HPLC analysis results of 5-HT,5-HIAA and 5-HIAA/5-HT in the hippocampus and hypothalamus of foetuses

From: Pre-gestational stress reduces the ratio of 5-HIAA to 5-HT and the expression of 5-HT1A receptor and serotonin transporter in the brain of foetal rat

Groups n Position 5-HT (ng/g) 5-HIAA (ng/g) 5-HIAA/5-HT
Female foetuses of control 47 Hippocampus 215.4 ± 15.8 165.1 ± 9.6 0.771 ± 0.041
    (210.8~220.0) (162.3~167.9) (0.759~0.783)
   Hypothalamus 116.9 ± 8.2 44.5 ± 5.5 0.382 ± 0.021
    (114.5~119.3) (42.9~46.1) (0.376~0.388)
Female foetuses of CUS 43 Hippocampus 236.3 ± 16.1** 135.8 ± 15.7** 0.572 ± 0.059**
    (231.3~241.3) (130.9~140.7) (0.554~0.590)
   Hypothalamus 146.7 ± 13.8** 46.1 ± 3.3 0.313 ± 0.052**
    (142.5~150.9) (45.1~47.2) (0.297~0.329)
Male foetuses of control 40 Hippocampus 206.7 ± 16.4 173.2 ± 12.8 0.84 ± 0.069
    (201.4~212.0) (169.1~177.3) (0.818~0.862)
   Hypothalamus 141.6 ± 15.2 54.9 ± 3.8 0.391 ± 0.044
    (136.7~146.5) (53.7~56.1) (0.377~0.405)
Male foetuses of CUS 49 Hippocampus 238.5 ± 10.5** 149.3 ± 10.2** 0.633 ± 0.07**
    (235.5~241.5) (146.4~152.2) (0.613~0.653)
   Hypothalamus 175.3 ± 13.3** 53.2 ± 6.3 0.312 ± 0.042**
    (171.5~179.1) (51.4~55.0) (0.300~0.324)
  1. Data are mean ± S.D. Data in bracket are 95% confidence intervals for each relevant statistic. **: P < 0.01 compared with control by the same sex and the same position
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