Table 1 Proteomic profile of micriglial-derived exosomes induced by Wnt3a treatment
From: Wnt3a induces exosome secretion from primary cultured rat microglia
Protein | MW (Da) | Peptides matched | Function |
|---|---|---|---|
Laminin subunit beta-1 | 196776 | 1 | Basement membrane |
Clathrin heavychain 1 | 191477 | 9 | Membrane trafficing |
Laminin subunit gamma-1 | 177185 | 2 | Basement membrane |
Alpha-1-macroglobulin | 167019 | 1 | Inhibits proteases |
Peroxidasin homolog | 165029 | 16 | ECM peroxidase (basement membrane) |
Nidogen-1 | 136536 | 1 | Basement membrane |
Adipocyte enhancer-building protein 1 | 130847 | 4 | Transcriptional repressor (cholesterol metabolism) |
Major vault protein | 95739 | 5 | Drug resistance |
Transitional endoplasmatic reticulum ATPase | 89293 | 8 | Budding of vesicels from ER |
Integrin beta-2 | 84970 | 2 | Cell adhesion |
Heat shock protein HS 90-alpha | 84762 | 1 | Chaperone (folding of cyctolic proteins) |
V-type proton ATPases catalytic subunit A | 68283 | 1 | Proton pump |
Transketolase | 67601 | 1 | Cytosolic metabolic enzyme |
Galectin-3-binding protein | 63701 | 1 | Cell adhesion via integrins |
Dihydropyrimidinase-related protein | 62157 | 1 | CRMP (schizophrenia risk gene) development |
ATP synthase subunit alpha, mitochondrial | 59717 | 3 | Mitochondrial enzyme |
T-complex protein 1 subunit eta | 59614 | 1 | Chaperone (folding of cytosolic proteins) |
Pyruvate kinase isozymes M1/M2 | 57781 | 7 | Glycolysis (cytosol) |
T-complex protein 1 subunit beta | 57422 | 1 | Chaperone (folding of cytosolic proteins) |
Matrix metalloproteinase-19 | 57321 | 2 | Secreted protease (ECMremodelling) |
Cystosol aminopeptidase | 56115 | 1 | Protein turnover |
Vitronectin | 54271 | 1 | Extracellular matrix |
Lipoprotein lipase | 53049 | 2 | Lipid hydrolysis |
Tubulin alpha-1B chain | 50120 | 3 | Structural |
Tubulin beta-5 chain | 49639 | 4 | Structural |
Actin, cytoplasmic 2 | 41766 | 28 | Structural |
Actin, cytoplasmic 1 | 41710 | 3 | Structural |
Protein Wnt-3a | 39232 | 15 | Treatment |
Annexin A2 | 38654 | 2 | Structural/ inhibits phospolipase A2 (anti inflam)/Apoptosis |
Annexin A3 | 36341 | 9 | Structural/ inhibits phospolipase A2 (anti inflam)/Apoptosis |
Annexin A4 | 35826 | 2 | Structural/ inhibits phospolipase A2 (anti inflam)/Apoptosis |
Apolipoprotein E | 35731 | 10 | Lipoprotein |
Glyceraldehyde-3-phosphate dehydrogenase | 35725 | 8 | Glycolysis(cytosol) |
Annexin A5 | 35722 | 1 | Structural/ inhibits phospolipase A2 (anti inflam)/Apoptosis |
40S ribosomal protein SA | 32803 | 3 | Protein synthesis |
40S ribosomal protein SA | 32803 | 1 | Protein synthesis |
40S ribosomal protein S3a | 29926 | 1 | Protein synthesis |
Proteasome subunit beta type-7 | 29908 | 2 | Proteasomal degradation |
40S ribosomal protein S3 | 26657 | 5 | Protein synthesis |
Proteinsome subunit alpha type-2 | 25910 | 1 | Proteasomal degradation |
40S ribosomal protein S8 | 24190 | 2 | Protein synthesis |
40S ribosomal protein S5 | 22864 | 1 | Protein synthesis |
Ferritin heavy chain | 21113 | 2 | Intracellular iron storage |
Ferritin light chain 1 | 20736 | 10 | Intracellular iron storage |
Ubiquitin | 8560 | 1 | Proteasomal degradation |