Longitudinal diffusion tensor imaging in amyotrophic lateral sclerosis

BMC Neuroscience

Table 3 Results of direct comparisons of ALS patients and correlation analysis

	Side	Cluster size	x	y	z	T	p
Paired t-test FA T0 / Follow-up
Temporal Lobe, Superior Temporal Gyrus, GM, BA 39	l	879	-49	-62	28	7.5	0.001*
Temporal Lobe, Superior Temporal Gyrus, GM, BA 39	l		-56	-64	16	4.82	0.033*
Parietal Lobe, Supramarginal Gyrus, GM, BA 40	l		-58	-61	30	4.19	0.075*
Cerebellum, Posterior Lobe, Declive	r	921	24	-59	-25	6.88	0.002*
Cerebellum, Anterior Lobe, Culmen	r		34	-52	-21	4.25	0.07*
Precentral Gyrus, WM	r	743	44	-9	41	6.67	0.003*
Precentral Gyrus, WM	r		53	-6	43	5.56	0.012*
Superior Temporal Gyrus, WM	r	2014	65	-39	10	6.36	0.004*
Superior Temporal Gyrus, GM, BA 22	r		61	-59	16	5.95	0.008*
Superior Temporal Gyrus, GM, BA 22	r		65	-48	20	5.12	0.022*
Parietal Lobe, Precuneus, WM	r	582	35	-74	39	6.21	0.005*
Brainstem, Midbrain, CST	r	270	16	-16	-17	5.89	0.008*
Temporal Lobe	r	756	44	8	-42	5.72	0.01*
Superior Frontal Gyrus, WM	r	221	35	39	35	5.27	0.018*
Middle Frontal Gyrus, subgyral, WM	r		29	34	31	4.76	0.035*
Superior Frontal Gyrus, GM, BA 11	r	487	28	45	-18	4.90	0.03*
Temporal Lobe, Middle Temporal Gyrus, WM	r	253	60	-7	-9	4.77	0.035*
Temporal Lobe, Superior Temporal Gyrus, WM	r		57	-2	3	4.33	0.063*
Paired t-test ADC T0 / Follow-up
Extra-Nuclear, WM, External capsule	l	2054	-28	2	-3	6.38	0.003*
Extra-Nuclear, WM, External capsule	l		-29	-15	11	6.16	0.004*
Extra-Nuclear, WM, External capsule	l		-25	-1	8	5.5	0.01*
Extra-Nuclear, WM, Internal capsule	l	383	-19	8	3	5.94	0.005*

ISSN: 1471-2202