Evaluation of cell proliferation, apoptosis, and dna-repair genes as potential biomarkers for ethanol-induced cns alterations

Table 1 Ethanol-induced gene expression changes in human lymphoblasts

Gene	Log2 Change	T test P	Mann–Whitney P
*TP73*	*-0.24*	*0.0076*	*0.0495*
*HUS1*	*-0.33*	*0.0186*	*0.0495*
*GADD45A*	*-0.38*	*0.0272*	*0.0495*
*ATM*	*-0.30*	0.0525	*0.0495*
CASP3	-0.31	0.0725	0.1266
*PTTG1*	*-0.11*	0.0764	*0.0495*
CCND1	-0.44	0.1024	0.1266
CDK1	-0.37	0.1143	0.1266
CDC25C	-0.29	0.1196	0.1266
*MUTYH*	*-0.25*	0.1658	*0.0495*
ERCC1	-0.19	0.1724	0.1266
*CD40*	*-0.46*	0.1801	*0.0495*
CCNB2	-0.12	0.2423	0.5127
ATR	-0.23	0.2561	0.1266
CHEK1	-0.17	0.2595	0.1266
CDK4	0.09	0.3009	0.5127
E2F3	-0.34	0.3205	0.2752
CCNA2	-0.35	0.3559	0.5127
CASP8	-0.20	0.3597	0.2752
PCNA	-0.26	0.3729	0.5127
APEX1	0.09	0.3942	0.2752
PARP1	0.10	0.4639	0.2752
JUN	-0.22	0.5296	0.5127
XRCC5	0.05	0.5766	0.5127
FADD	-0.09	0.5912	0.5127
FASLG	-0.37	0.6082	0.8273
TNFRSF10B	0.06	0.6242	0.5127
RACGAP1	-0.15	0.6435	0.8273
APAF1	-0.08	0.8085	0.8273
MDM4	-0.06	0.8190	0.5127
TP53	-0.07	0.8410	0.8273
HPRT1	0.00	0.8822	0.5127
PPIA	0.00	0.8917	0.5127
BCL2	0.03	0.8928	0.8273
MCM5	-0.02	0.9212	0.5127
MYC	0.02	0.9242	0.8273

These genes represent the complete set of genes analyzed by QuantiGene Plex 2.0. assays in cultured human lymphoblasts as well as primary human and rat PBLs.
Nominally significant observations are indicated in boldface italics.

ISSN: 1471-2202