Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?

Table 2 Over-represented KEGG pathways in the ILmPFC, 24h post stress according to DAVID

KEGG pathway	pvalue*	Fold Enrichment	Benjamini	FDR	Genes
Neurotrophin signaling pathway (04722)	<0.001	6.239	0.006	0.078	BRAF, RGD1306565, CAMK2G, PTPN11, NTRK3, MAP3K5, GSK3B, NTRK2, PIK3CA, LOC685605, CAMK2A, LOC685653, LOC685626, LOC685590
ErbB signaling pathway (04012)	0.003	6.165	0.101	2.694	CBLB, BRAF, GSK3B, CAMK2G, PIK3CA, LOC685605, CAMK2A, LOC685626, LOC685653, LOC685590
Long-term potentiation (04720)	0.007	6.518	0.169	6.868	GRIN2B, BRAF, CAMK2G, GRIN2A, CAMK2A
Axon guidance (04360)	0.014	4.126	0.252	13.797	EPHA5, SEMA6A, NRP1, PLXNA2, GSK3B, UNC5C
Cell adhesion molecules (04514)	0.025	3.541	0.346	23.766	GLG1, NCAM1, ALCAM, NLGN2, NEO1, NEGR1
Amyotrophic lateral sclerosis (05014)	0.028	5.922	0.332	26.567	SLC1A2, MAP3K5, RGD1306565, GRIN2B, GRIN2A
Glioma (05214)	0.031	5.727	0.314	28.605	BRAF, CAMK2G, PIK3CA, LOC685605, CAMK2A, LOC685626, LOC685653, LOC685590
Phosphatidylinositol signaling system (04070)	0.044	4.991	0.375	38.162	SYNJ1, PIK3CA, LOC685605, LOC497978, LOC685626, LOC685653, PIP4K2B, LOC685590

ISSN: 1471-2202