The modular cross-synaptic nature of LTP/LTD following on-going neural activity
- Alex Loebel†1Email author,
- Jean-Vincent Le Bé†2,
- Magnus JE Richardson3,
- Andreas Herz1 and
- Henry Markram2
© Loebel et al; licensee BioMed Central Ltd. 2011
Published: 18 July 2011
While synaptic efficacies are modified continuously by on-going spiking activity, it is yet unclear whether the underlying pre- and post-synaptic processes occur independently, or in accordance. To elucidate the effects of sustained spiking communication on synaptic properties, we patch-clamped paired pyramidal neurons in-vitro at both ends of 12h intervals of spontaneous or glutamate-induced spiking activity. We found that the synaptic efficacies either increased, or decreased, with the ratio between the second and first measurement ranging between 0.08-14. Using quantal and failure analyses we show that this slow form of long-term potentiation and depression is explained by changes in the estimated number of release sites, alongside overall post-synaptic changes that maintain the quantal size per release site. Our findings suggest that sustained neural activity results in matched pre- and post-synaptic modifications, in which elementary modules that span the synaptic cleft are added or subtracted as a function of experience.
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